Human capital is the main asset ISSNAF relies on to implement its mission and successfully perform its role of "Hub of Eccellence".

Under the auspices of the Italian Ambassador to the United States, ISSNAF was established in 2008 by 37 prominent Italian scientists and scholars in North America, amongst them four Nobel Prizes.

• Alberto AlesinaHarvard University
• Michele BoldrinWashington University
• Vito M. CampeseUniversity of Southern California
• Luigi Cavalli SforzaStanford University
• Carlo CroceOhio University

  NAS 1996

• Nicola Di CosmoIAS, Princeton
• Mario GerlaUCLA
• Roberto PecceiUCLA
• Camillo RicordiUniversity of Miami
• Pierluigi ZappacostaSBC Global, Digital Persona e Faro Ventures
• Piero AnversaHarvard University
• Enrico BombieriIAS, Princeton

  Fields Medal 1974, Balzan Prize 1980,
  NAS 1996

• Federico CapassoHarvard University

  NAS 1996

• Rita R. ColwellFormer Director NSF

  NAS 2000

• Pietro De CamilliYale University

  NAS 2001

• Renato DulbeccoNobel per la Medicina 1975; NAS 1961
  1914-2012 
• Riccardo Giacconi

  Nobel Prize for Physics 2002; NAS 1971

• Massimo Piattelli-PalmariniUniversity of Arizona
• Alberto Sangiovanni VincentelliBerkeley; Cadence, Synopsys

  Clerk Maxwell Award '09

• Giorgio BellettiniFermi Laboratory

  Matteucci Medal 2006

• George BugliarelloNYU
  1927-2011
• Mario CapecchiUniversity of Utah

  Nobel Prize in Medicine 2007, NAS 1991

• Bruno CoppiMIT

  Clerk Maxwell Prize 1987

• Giulio Della RoccaCalstate University, Long Beach
• Franco EinaudiGoddard Space Flight Center, NASA
• Louis IgnarroUCLA

  Nobel Prize for Medicine 1998; NAS 1999

• Tomaso A. PoggioMIT

  AAAS Fellow

• Achille VarziColumbia University
• Emilio BizziMIT

  NAS 1986

• Guido CalabresiYale University
• Roberto CarPrinceton University
• Roberto CreaCrea Group
• Francesco Della PortaEdmund Mach Foundation
• Mauro FerrariUniversity of Texas
• Paolo PaolettiSenior Vice President, Glaxo
• Elio RaviolaHarvard University
• Andrew ViterbiLinkabit e Qualcomm

  Clerk Maxwell Award 2007; NAS 1996; IEEE Medal of Honor 2010