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PhD scholarships at IMT Lucca

2018/19 PhD programs at the IMT School for Advanced Studies Lucca Deadline for applications – August 3rd 2018, 12 pm CEST Applications are now being accepted for the 2018/19 PhD Programs at the IM [ ... ]


ISSNAF Awards for Young Investigators - Call for Applications 2018

ISSNAF Board of Trustees encourages all Italian early-stage researchers currently primarily working in the United States or Canada to submit their application and research abstract to compete for one  [ ... ]


LAVORO L’Italia si svuota: raddoppiano i laureati in fuga all’estero di Enrico Marro

LAVORO L’Italia si svuota: raddoppiano i laureati in fuga all’estero di Enrico Marro
Clicca qui per leggere il post originale Il nostro Paese spende circa il 4% del Pil (stime Ocse) per l’int [ ... ]


IN ITALIA IL PRIMO EXPO MEETING DEDICATO ALLE INNOVAZIONI PER LA LONGEVITÁ

Dal 21 al 23 Giugno i protagonisti della Silver Economyriuniti nel nostro Paese per l’Expo-Meeting Innov-Aging Per tre giorni le Marche saranno la capitale della Silver Age ospitando Istituzi [ ... ]


Programma reclutamento giovani ricercatori "Rita Levi Montalcini"

Selezione dei beneficiari. Una commissione ministeriale procede poi a valutare le candidature. In base ai risultati della valutazione, i vincitori vengono chiamati e l’Università indicata dal vinci [ ... ]


Call for Applications 2018- Fondazione Pisana per la Scienza

RESEARCH GRANT APPLICATION The aim of this Call for Applications is to promote innovation in biomedical research by attracting talented researchers to join the Pisa scientific community. http://canad [ ... ]


Medico pratese vince borsa in USA per la ricerca contro il cancro

Luca Pasquini, giovane medico pratese, e' stato premiato dall' ISSNAF con una borsa che gli permetterà di proseguire i suoi studi sulla plasticità neuronale nel cancro cerebrale al Memorial Sloan Ke [ ... ]


Ricercatori: troppi cervelli in fuga, Italia tredicesima nella classifica dei più citati al mondo

La nostra nazione paga il solito prezzo: molti studiosi sono assoldati da atenei stranieri. L'Università di Bologna in testa con cinque citazioni. La rete scientifica di Milano a quota dieci di CORR [ ... ]


MEET THE AUTHORS Erri De Luca & Paolo Sassone-Corsi


The Director of the Italian Cultural Institute
cordially  invites you to
  Acclaimed Italian novelist Erri De Luca will present his latest book Diavoli Custodi (Feltrinelli, 2 [ ... ]


ISSNAF Board of Trustees: new board members

ISSNAF Board of Trustees: new board members The ISSNAF Board of Trustees welcomes four new Board Members* who represent some of the most innovative fields of technology and science. Their competence, [ ... ]


Nonsense mutations in DMD explained by Carmen Bertoni

bertoni 1Read-through of nonsense mutations in Duchenne muscolar dystrophy.
Duchenne muscular dystrophy (DMD) is a devastating disease caused by mutations in the gene called dystrophin. DMD-causing mutations vary in nature and account for deletion, replications, duplications or single point mutations which disrupt the coding reading frame of the dystrophin gene. The result is absence of dystrophin expression into skeletal and cardiac muscles. Among the single point mutations, 10 to 15% are, so called, nonsense mutations. They are caused by a change of a single base in the DNA that prematurely ends the translation of a gene into a protein. This occurs after the gene is translated into mRNA and during the translation of the mRNA into protein.

The result is the expression of a truncated (non-functional) protein. Certain compounds like gentamicin or more recently Ataluren (PTC124) have shown to suppress the mutation by interfering with the premature termination of protein synthesis during mRNA processing.

However, clinical trials using both drugs have produced only limited effects. During the past years, there has been increasing interest in identifying new drugs that could read through the premature stop codon and counteract the genetic defect.

In 2009, new read-through compounds (RTCs) with promising activity were identified at the University of California, Los Angeles (UCLA) using high throughput screening. This labor-intensive project sought the involvement of different groups and campus resources including the California NanoSystems Institute and the UCLA Molecular Shared Screening Resource center and was led by the laboratory of Dr. Richard Gatti, professor of pathology and laboratory medicine and of human genetics at the David Geffen School of Medicine. The screening of thousands of small molecules identified two promising RTCs. The results were published in the Journal of Experimental Medicine. In that article, my laboratory demonstrated the ability of RTC13 and RTC14 to suppress the nonsense mutation in muscle cells in culture isolated from the mdx, a mouse model for DMD.

These encouraging results have prompted my research group to further test the RTCs in vivo and to determine their therapeutic relevance for the treatment of DMD.

In the new study that we published in the journal of Human Molecular Genetics we demonstrate that RTC13 restores significant amounts of dystrophin into muscle and that the effects are superior to those seen with gentamicin or PTC124.

Importantly, our results demonstrate that even a limited number of treatments can achieve significant beneficial effects in the mouse model. The compound was well tolerated in animals suggesting that it could be safe to use in humans. These results are noteworthy because they open new hope for the treatment of qualifying DMD patients that could benefit from a drug that suppresses nonsense mutations.

The next step is to test whether an orally viable formulation of the drug can achieved sustained levels of dystrophin expression and its overall effects on muscle pathology. The work that lies ahead will determine whether the drug can be moved into clinical trials and has reasonable chances of entering the clinic.

The cost of developing a drug, from its early stages of drug discovery to its first testing in humans and its commercialization has been estimated to be in the range of 10 to 14 million dollars and in difficult economical times such the current ones, it is not easy for many laboratories to find this type of resources.

We owe much of the success achieved with RTC13 to the Muscular Dystrophy Association of the US, the world’s largest non-profit organization sponsoring research for neuromuscular disorders.

The MDA has supported the preclinical studies in the mdx mouse and has allowed us to gather the preliminary data necessary to obtain additional funding from federal agencies like the National Institute of Health (NIH).

In my opinion, this is a perfect example of how everybody can make an impact in advancing basic and clinical research through donations. We hope our studies will ultimately lead to the development of an effective therapy that could benefit thousands of patients diagnosed worldwide.

Carmen Bertoni

 
ISSNAF Annual Event
ISSNAF Annual Event
"Science & the New Industrial Revolution: Industry 4.0"

was the focus of 2017 edition of the ISSNAF annual event, which took place on the 7th and 8th of November at the Italian Embassy in Washington D.C.

Exponents from the world of science, business, and federal agencies of the United States exchanged views on the impact that artificial intelligence and the Internet of Things, applied to productive processes, are having on science, on the academic world, and on our daily lives.


ISSNAF Speeches
Claudio Pellegrini gave his speech during the event "Fermi's Legacy: from La Sapienza to the Bay Area", organized by the Consulate General of Italy in San Francisco, the Italian Cultural Institute, and the ISSNAF Bay Area Chapter on May 5th, 2018. The event, hosted by the Italian Cultural Institute of San Francisco, was organized for the first Italian Research in the World Day, a new initiative launched by the Italian Ministry of Education, University and Research (MIUR) to recognize the important work of Italian scientists and researchers in the world.
Pellegrini is a Distinguished Professor of Physics Emeritus at UCLA – University of California, Los Angeles. In 2015, President Barack Obama presented Pellegrini the Enrico Fermi Award, a one of the government’s oldest and most prestigious awards for scientific achievement.
In his speech he shared his experience spanning over six decades of scientific accomplishments from the Physics department at La Sapienza in Rome to the national laboratories of the Bay Area, as well as his views on the impact his field has had on society at large.


 
Lina Gualtieri gave her speech during the event "Fermi's Legacy: from La Sapienza to the Bay Area", organized by the Consulate General of Italy in San Francisco, the Italian Cultural Institute, and the ISSNAF Bay Area Chapter on May 5th, 2018. The meeting, hosted by the Italian Cultural Institute of San Francisco, was organized for the first Italian Research In the World Day, a new initiative launched by the Italian Ministry of Education, University and Research (MIUR) to recognize the important work of Italian scientists and researchers in the world.
Galtieri headed a number of important projects at the Lawrence Berkeley National Laboratory of the University of California, and contributed to important experiments at CERN, SLAC and Fermilab.
In her speech she shared her experience spanning over six decades of scientific accomplishments from the Physics department at La Sapienza in Rome to the national laboratories of the Bay Area, as well as her views on the impact her field has had on society at large.

Young ISSNAF

Young ISSNAFYoung ISSNAF is the “network-inside-the-network” of under-40 ISSNAF affiliates, Italian investigators and scholars of all areas of scientific and academic research.

Click here to read more

 

Success Stories

Young ISSNAFOur pride is to be able to help young Italian talents follow their dreams and have opportunities.

Here is where they share them.

Click here to read more

Inside ISSNAF

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Samanta Cristoforetti in conversation Samanta Cristoforetti in conversation

  The Consulate General of Italy, the Italian Cultural Institute and the Emilio Goggio Chair in Italian Studies, University of Toronto proudly present Samanta Cristoforetti, Italian astronaut, European Space Agency in conversation with Canadian astronaut Roberta Bondar FUTURA Mission - 200 ...

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La Console Natalia Quintavalle consegna l'onorificenza di Grande Ufficiale alla Dott.ssa Silvia Formenti, una luminare nel campo della radioterapia La Console Natalia Quintavalle consegna l'onorificenza di Grande Ufficiale alla Dott.ssa Silvia Formenti, una luminare nel campo della radioterapia

      La Dott.ssa Silvia Formenti, membro del Board of Trustees di ISSNAF e presidente dell'Advisory Board di Medicina e Biologia, ha ricevuto il 2 giugno 2015, durante le celebrazioni delle Festa della Repubblica, l'onorificenza di Grande Ufficiale dalla Console Generale d'Italia ...

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ISSNAF Medical Imaging Science Chapter 2015 Meeting ISSNAF Medical Imaging Science Chapter 2015 Meeting

Saturday, March 7th, 2015 from 12:00 to 14:00pm Meeting Room: 2.95 The meeting, held in English, is open to Italians, Italian-Americans, and Italian sympathizers For more information email imaging@issnaf.org or call Lorenzo Mannelli at +1 (646) 226 5924

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ISSNAF-Seattle Chapter Winter 2015 Meeting ISSNAF-Seattle Chapter Winter 2015 Meeting

Thursday , January 29th, 2015 early afternoonat the laboratories of Global Good-Intellectual Ventures the ISSNAF-Seattle Chapter Winter 2015 Meeting will take place. The meeting, held in English, is open to Italians, Italian-Americans, and Italian sympathizers For more information email seattle@iss...

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ISSNAF Medical Imaging Science Chapter Meeting ISSNAF Medical Imaging Science Chapter Meeting

Sunday, November 30th, 2014 from 12pm to 1:30pm Meeting Room: E271B The meeting, held in English, is open to Italians, Italian-Americans, and Italian sympathizers For more information email imaging@issnaf.org or call Lorenzo Mannelli at +1 (646) 226 5924

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ISSNAF - Fondazione Marche Internships 2014 ISSNAF - Fondazione Marche Internships 2014

 ISSNAF and Fondazione Marche are honored to announce the winners of the ECapital contest. The competition, aimed to encourage the creation of innovative business ideas, is a unique opportunity to transform creativity into business and is giving away for the winners 5 internship at "Mind the B...

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Meeting with Italy's Minister of Health, Beatrice Lorenzin Meeting with Italy's Minister of Health, Beatrice Lorenzin

  On Saturday, May 31th, 2014, a delegation of Italian researchers participated in a meeting with Italy's Minister of Health, Beatrice Lorenzin, and Sergio Pecorelli, Chancellor at the University of Brescia and President of the Italian Medicines Agency.

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Medical Imaging Science Chapter @ SIRM 2014 Medical Imaging Science Chapter @ SIRM 2014

On Saturday May the 25th, during the biannual meeting of the Societa' Italiana di Radiologia Medica (SIRM), the Medical Imaging Science Chapter of ISSNAF organized a round table to discuss the experiences of Italian radiologists abroad.

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Los Angeles Mayor Garcetti meets ISSNAF Los Angeles Mayor Garcetti meets ISSNAF

  Los Angeles Mayor Eric Garcetti met with ISSNAF President Vito Campese during a meeting with the Italian community hosted by Consul General Giuseppe Perrone on May 20, 2014. Mayor Garcetti was very supportive and showed interested in ISSNAF activities. 

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ITALIAN BEAUTIFUL MINDS an Italian contribution ITALIAN BEAUTIFUL MINDS an Italian contribution

Meeting organized by the Consulate General of Italy, the Italian Cultural Institute, and ISSNAF on Wednesday, June 4, 2014 6:30pm at the IIC, 1023 Hilgard Avenue, Los Angeles CA 90024. RSVP to rsvp.iicla@esteri.it  

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Medical Imaging Science Chapter @ SIRM Medical Imaging Science Chapter @ SIRM

  The ISSNAF Medical Imaging Science Chapter will hold a roundtable during the 2014 Meeting of the Societa’ Italiana di Radiologia Medica (SIRM). The discussion will highlight different research experiences of Italian scientists in North America and promote future collaborations between medic...

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ISSNAF Seattle Chapter Summer Meeting ISSNAF Seattle Chapter Summer Meeting

The 2014 ISSNAF-Seattle Chapter (near) Summer meeting will take place on Wednesday, June 4th in the Bellevue Arts Museum (BAM, 510 Bellevue Way NE, Bellevue, WA 98004) from 5.30pm to 8.00 pm. Guest speakers: Mark Nassutti, novelist, will talk about how his Italian roots made possible to write a no...

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2014 ISSNAF Awards for the Humanities 2014 ISSNAF Awards for the Humanities

ISSNAF and LaFondazioneNY encourage all Italian researchers born after March 30, 1974 and currently primarily working in the United States or Canada to submit their full applications.

DEADLINE EXTENDED APRIL 25, 2014.

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Internship Program ISSNAF-ASI 2014 Internship Program ISSNAF-ASI 2014

Thanks to the generous support of Agenzia Spaziale Italiana (ASI) ISSNAF is offering two summer internships in primary North American research facilities.

DEADLINE EXTENDED APRIL 10, 2014.


Read the call - Get Application form - Learn more about ASI.

ISSNAF Seminar @ NY Chapter ISSNAF Seminar @ NY Chapter

The first ISSNAF Seminar of 2014, "Italy 2020: Challenges and Opportunities of Growth", was organized by the New York Chapter on February 28th at the Italian Cultural Institute in New York. Approximately 130 people gathered to listen to our amazing speakers and the event was truly a success.

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ISSNAF Seattle Chapter Spring Meeting ISSNAF Seattle Chapter Spring Meeting

The 2014 Spring meeting will take place on Thursday, April 10th in the Auditorium of the Research and Training Building (300 9th Ave, 98104, Seattle) at Harborview Medical Center. We are pleased to host four outstanding speakers: Erica Tartaglione, Research Specialist at the VA Puget Sound Hospit...

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Issa Wiki

ISSA WIKIItalian Scientists & Scholars in America Online Encyclopedia.
 

A comprehensive overview on Italian intellectual migration, from its origins in the 16th century until this day.
 

An encyclopedia studying the influence and contribution of Italians on cultural life in the United States and Canada.

issawiki.org