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Giuseppe Cataldo awarded the 2017 NASA Early Career Public Achievement Medal

Giuseppe Cataldo received the 2017 NASA Early Career Public Achievement Medal "for exceptional insight and tireless efforts to bring advanced mathematical methods to the correlation of thermal models  [ ... ]


Aspen Institute Italia Award – 2018

Aspen Institute Italia (www.aspeninstitute.it) established, in 2016, an annual award for 40,000 euros which honors a research contribution in the field of natural, theoretical, or applied sciences pro [ ... ]


The Bay Area Chapter is off to a great start!

The Bay Area Chapter of ISSNAF  was established on September 9, 2017 to connect and support the large number  of Italian researchers and scholars based in the Greater San Fran [ ... ]


Laura e Luca, coppia di scienza italiana in USA per amore della ricerca medica

Chi parte sa da che cosa fugge ma non sa che cosa trova? Questa volta no perché per Luca Bartolini, pediatra che lavora al National Institute of Neurological Disorders and Stroke di Washington D.C,  [ ... ]


GIUSEPPE CORRIAS MD, RADIOLOGY RESIDENT AT UNIVERSITY OF CAGLIARI, RECEIVED THE ISSNAF MEDICAL IMAGING SCIENCE CHAPTER AWARD AND WILL SPEND ONE YEAR AS A RESEARCH FELLOW AT THE MEMORIAL SLOAN KETTERING CANCER CENTER (MSKCC), NEW YORK

Congratulations to Dr. Giuseppe Corrias on receiving a 10.500 dollars award from ISSNAF MEDICAL IMAGING SCIENCE Chapter of for a one-year research fellowship on cancer research with focus on Magnetic  [ ... ]


Simone Mori MD, working at Conti Lab at Scripps in San Diego and ISSNAF affiliate, won the Merck Biopharma Innovation Cup

Ciprofloxacin is an antibiotic for treatment of a wide spectrum of bacteria. The drug does not perform any positive effect on viruses, protozoa or fungal infections, however it can mask or delay certa [ ... ]


Vincenzo Piuri, Full Professor at the Department of Computer Science, University of Milano is a candidate for 2018 IEEE President-Elect

Vincenzo Piuri, Full Professor at the Department of Computer Science, University of Milano is a candidate for 2018 IEEE President-Elect, who will then serve as 2019 IEEE President. Below you find his  [ ... ]


Young Investigator Training Program - ACRI (Associazione di Fondazioni e Casse di Risparmio Italiane)

ACRI (Associazione di Fondazioni e Casse di Risparmio Italiane) is sponsoring a limited number of research prizes for young investigators thanks to the "Young Investigator Training Program". Awar [ ... ]


Award for Innovation & Circular Economy - Winner announced

Press Release   New York -  June, 20 2017     ISSNAF, the Italian Scientists and Scholars in North America Foundation, and Intesa Sanpaolo, the leading banking group in Italy  [ ... ]


Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells

Stress signals improve tumor fitness
Jeffrey J. Rodvold, Kevin T. Chiu, Nobuhiko Hiramatsu, Julia K. Nussbacher, Valentina Galimberti, Navin R. Mahadevan, Karl Willert, Jonathan H. Lin, and Maurizio Za [ ... ]


Nonsense mutations in DMD explained by Carmen Bertoni

bertoni 1Read-through of nonsense mutations in Duchenne muscolar dystrophy.
Duchenne muscular dystrophy (DMD) is a devastating disease caused by mutations in the gene called dystrophin. DMD-causing mutations vary in nature and account for deletion, replications, duplications or single point mutations which disrupt the coding reading frame of the dystrophin gene. The result is absence of dystrophin expression into skeletal and cardiac muscles. Among the single point mutations, 10 to 15% are, so called, nonsense mutations. They are caused by a change of a single base in the DNA that prematurely ends the translation of a gene into a protein. This occurs after the gene is translated into mRNA and during the translation of the mRNA into protein.

The result is the expression of a truncated (non-functional) protein. Certain compounds like gentamicin or more recently Ataluren (PTC124) have shown to suppress the mutation by interfering with the premature termination of protein synthesis during mRNA processing.

However, clinical trials using both drugs have produced only limited effects. During the past years, there has been increasing interest in identifying new drugs that could read through the premature stop codon and counteract the genetic defect.

In 2009, new read-through compounds (RTCs) with promising activity were identified at the University of California, Los Angeles (UCLA) using high throughput screening. This labor-intensive project sought the involvement of different groups and campus resources including the California NanoSystems Institute and the UCLA Molecular Shared Screening Resource center and was led by the laboratory of Dr. Richard Gatti, professor of pathology and laboratory medicine and of human genetics at the David Geffen School of Medicine. The screening of thousands of small molecules identified two promising RTCs. The results were published in the Journal of Experimental Medicine. In that article, my laboratory demonstrated the ability of RTC13 and RTC14 to suppress the nonsense mutation in muscle cells in culture isolated from the mdx, a mouse model for DMD.

These encouraging results have prompted my research group to further test the RTCs in vivo and to determine their therapeutic relevance for the treatment of DMD.

In the new study that we published in the journal of Human Molecular Genetics we demonstrate that RTC13 restores significant amounts of dystrophin into muscle and that the effects are superior to those seen with gentamicin or PTC124.

Importantly, our results demonstrate that even a limited number of treatments can achieve significant beneficial effects in the mouse model. The compound was well tolerated in animals suggesting that it could be safe to use in humans. These results are noteworthy because they open new hope for the treatment of qualifying DMD patients that could benefit from a drug that suppresses nonsense mutations.

The next step is to test whether an orally viable formulation of the drug can achieved sustained levels of dystrophin expression and its overall effects on muscle pathology. The work that lies ahead will determine whether the drug can be moved into clinical trials and has reasonable chances of entering the clinic.

The cost of developing a drug, from its early stages of drug discovery to its first testing in humans and its commercialization has been estimated to be in the range of 10 to 14 million dollars and in difficult economical times such the current ones, it is not easy for many laboratories to find this type of resources.

We owe much of the success achieved with RTC13 to the Muscular Dystrophy Association of the US, the world’s largest non-profit organization sponsoring research for neuromuscular disorders.

The MDA has supported the preclinical studies in the mdx mouse and has allowed us to gather the preliminary data necessary to obtain additional funding from federal agencies like the National Institute of Health (NIH).

In my opinion, this is a perfect example of how everybody can make an impact in advancing basic and clinical research through donations. We hope our studies will ultimately lead to the development of an effective therapy that could benefit thousands of patients diagnosed worldwide.

Carmen Bertoni

 
ISSNAF Annual Event
ISSNAF Annual Event
"Science & the New Industrial Revolution: Industry 4.0"

was the focus of 2017 edition of the ISSNAF annual event, which took place on the 7th and 8th of November at the Italian Embassy in Washington D.C.

Exponents from the world of science, business, and federal agencies of the United States exchanged views on the impact that artificial intelligence and the Internet of Things, applied to productive processes, are having on science, on the academic world, and on our daily lives.


Young ISSNAF

Young ISSNAFYoung ISSNAF is the “network-inside-the-network” of under-40 ISSNAF affiliates, Italian investigators and scholars of all areas of scientific and academic research.

Click here to read more

 

Success Stories

Young ISSNAFOur pride is to be able to help young Italian talents follow their dreams and have opportunities.

Here is where they share them.

Click here to read more

ISSNAF Video

Inside ISSNAF

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Samanta Cristoforetti in conversation Samanta Cristoforetti in conversation

  The Consulate General of Italy, the Italian Cultural Institute and the Emilio Goggio Chair in Italian Studies, University of Toronto proudly present Samanta Cristoforetti, Italian astronaut, European Space Agency in conversation with Canadian astronaut Roberta Bondar FUTURA Mission - 200 ...

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La Console Natalia Quintavalle consegna l'onorificenza di Grande Ufficiale alla Dott.ssa Silvia Formenti, una luminare nel campo della radioterapia La Console Natalia Quintavalle consegna l'onorificenza di Grande Ufficiale alla Dott.ssa Silvia Formenti, una luminare nel campo della radioterapia

      La Dott.ssa Silvia Formenti, membro del Board of Trustees di ISSNAF e presidente dell'Advisory Board di Medicina e Biologia, ha ricevuto il 2 giugno 2015, durante le celebrazioni delle Festa della Repubblica, l'onorificenza di Grande Ufficiale dalla Console Generale d'Italia ...

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ISSNAF Medical Imaging Science Chapter 2015 Meeting ISSNAF Medical Imaging Science Chapter 2015 Meeting

Saturday, March 7th, 2015 from 12:00 to 14:00pm Meeting Room: 2.95 The meeting, held in English, is open to Italians, Italian-Americans, and Italian sympathizers For more information email imaging@issnaf.org or call Lorenzo Mannelli at +1 (646) 226 5924

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ISSNAF-Seattle Chapter Winter 2015 Meeting ISSNAF-Seattle Chapter Winter 2015 Meeting

Thursday , January 29th, 2015 early afternoonat the laboratories of Global Good-Intellectual Ventures the ISSNAF-Seattle Chapter Winter 2015 Meeting will take place. The meeting, held in English, is open to Italians, Italian-Americans, and Italian sympathizers For more information email seattle@iss...

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ISSNAF Medical Imaging Science Chapter Meeting ISSNAF Medical Imaging Science Chapter Meeting

Sunday, November 30th, 2014 from 12pm to 1:30pm Meeting Room: E271B The meeting, held in English, is open to Italians, Italian-Americans, and Italian sympathizers For more information email imaging@issnaf.org or call Lorenzo Mannelli at +1 (646) 226 5924

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ISSNAF - Fondazione Marche Internships 2014 ISSNAF - Fondazione Marche Internships 2014

 ISSNAF and Fondazione Marche are honored to announce the winners of the ECapital contest. The competition, aimed to encourage the creation of innovative business ideas, is a unique opportunity to transform creativity into business and is giving away for the winners 5 internship at "Mind the B...

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Meeting with Italy's Minister of Health, Beatrice Lorenzin Meeting with Italy's Minister of Health, Beatrice Lorenzin

  On Saturday, May 31th, 2014, a delegation of Italian researchers participated in a meeting with Italy's Minister of Health, Beatrice Lorenzin, and Sergio Pecorelli, Chancellor at the University of Brescia and President of the Italian Medicines Agency.

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Medical Imaging Science Chapter @ SIRM 2014 Medical Imaging Science Chapter @ SIRM 2014

On Saturday May the 25th, during the biannual meeting of the Societa' Italiana di Radiologia Medica (SIRM), the Medical Imaging Science Chapter of ISSNAF organized a round table to discuss the experiences of Italian radiologists abroad.

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Los Angeles Mayor Garcetti meets ISSNAF Los Angeles Mayor Garcetti meets ISSNAF

  Los Angeles Mayor Eric Garcetti met with ISSNAF President Vito Campese during a meeting with the Italian community hosted by Consul General Giuseppe Perrone on May 20, 2014. Mayor Garcetti was very supportive and showed interested in ISSNAF activities. 

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ITALIAN BEAUTIFUL MINDS an Italian contribution ITALIAN BEAUTIFUL MINDS an Italian contribution

Meeting organized by the Consulate General of Italy, the Italian Cultural Institute, and ISSNAF on Wednesday, June 4, 2014 6:30pm at the IIC, 1023 Hilgard Avenue, Los Angeles CA 90024. RSVP to rsvp.iicla@esteri.it  

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Medical Imaging Science Chapter @ SIRM Medical Imaging Science Chapter @ SIRM

  The ISSNAF Medical Imaging Science Chapter will hold a roundtable during the 2014 Meeting of the Societa’ Italiana di Radiologia Medica (SIRM). The discussion will highlight different research experiences of Italian scientists in North America and promote future collaborations between medic...

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ISSNAF Seattle Chapter Summer Meeting ISSNAF Seattle Chapter Summer Meeting

The 2014 ISSNAF-Seattle Chapter (near) Summer meeting will take place on Wednesday, June 4th in the Bellevue Arts Museum (BAM, 510 Bellevue Way NE, Bellevue, WA 98004) from 5.30pm to 8.00 pm. Guest speakers: Mark Nassutti, novelist, will talk about how his Italian roots made possible to write a no...

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2014 ISSNAF Awards for the Humanities 2014 ISSNAF Awards for the Humanities

ISSNAF and LaFondazioneNY encourage all Italian researchers born after March 30, 1974 and currently primarily working in the United States or Canada to submit their full applications.

DEADLINE EXTENDED APRIL 25, 2014.

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Internship Program ISSNAF-ASI 2014 Internship Program ISSNAF-ASI 2014

Thanks to the generous support of Agenzia Spaziale Italiana (ASI) ISSNAF is offering two summer internships in primary North American research facilities.

DEADLINE EXTENDED APRIL 10, 2014.


Read the call - Get Application form - Learn more about ASI.

ISSNAF Seminar @ NY Chapter ISSNAF Seminar @ NY Chapter

The first ISSNAF Seminar of 2014, "Italy 2020: Challenges and Opportunities of Growth", was organized by the New York Chapter on February 28th at the Italian Cultural Institute in New York. Approximately 130 people gathered to listen to our amazing speakers and the event was truly a success.

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ISSNAF Seattle Chapter Spring Meeting ISSNAF Seattle Chapter Spring Meeting

The 2014 Spring meeting will take place on Thursday, April 10th in the Auditorium of the Research and Training Building (300 9th Ave, 98104, Seattle) at Harborview Medical Center. We are pleased to host four outstanding speakers: Erica Tartaglione, Research Specialist at the VA Puget Sound Hospit...

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Issa Wiki

ISSA WIKIItalian Scientists & Scholars in America Online Encyclopedia.
 

A comprehensive overview on Italian intellectual migration, from its origins in the 16th century until this day.
 

An encyclopedia studying the influence and contribution of Italians on cultural life in the United States and Canada.

issawiki.org