Pierluigi received the Laurea degree “cum laude” in electrical engineering from the University of Rome, Italy in 1974, and the Master of Science degree in computer science from Stanford University in 1978.

In 1981 he co-founded Logitech, a manufacturer of computer peripherals, where he served for 18 years first as President and CEO and later as Vice Chairman. He helped take Logitech public in Switzerland in 1988 and on NASDAQ in 1997. In 1996 he co-founded DigitalPersona, a biometry-based security company, and was its Chairman for several years. Between 2003 and 2013 he was CEO of Sierra Sciences, a biotech company working to extend the human health span. Currently he is an investor in technology companies in USA and Italy.

In 2007 he co-founded ISSNAF (Italian Scientists and Scholars in North America Foundation) and is currently its Secretary and Treasurer. In 2017 he co-founded the ISSNAF Bay Area Chapter and is currently its Chair. He is chairman of "Friends of Istituto Bruno Leoni" in USA and trustee of "Istituto Bruno Leoni" in Italy.

On June 2nd, 2003 he received the “Commendatore al Merito della Repubblica”. In October 2015, Pierluigi was knighted “Cavaliere del Lavoro” by the President of the Italian Republic.